Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Prince Miteb bin Abdullah, one of the most senior Saudi royals detained in the kingdom's corruption crackdown, has been released after reaching a settlement deal believed to exceed the equivalent of $1 billion, an official involved in the anti-graft campaign said.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The magazine put his net worth at $3.5 billion, down $1 billion from the rankings it issued a year ago.
Trends and targets in antiviral phototherapy
Revenge epic The Revenant was named best drama picture and DiCaprio and Inarritu walked to the stage to collect it together.
The central government has allocated a special fund of 100 billion yuan to provide assistance to workers laid off from overcapacity cuts, and also has asked local governments to set up matching funds.
Apple was the only top five PC maker to see shipments grow last year, up over 6%, while Acer saw the biggest fall, of more more than 18%.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
People with Type A personalities are often high-achieving "workaholics". They push themselves with deadlines, and hate both delays and ambivalence. People with Type A personalities experience more job-related stress and less job satisfaction.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
●"Cinnamon Roll Can Explodes Inside Man’s Butt During Shoplifting Incident"
One of the more unique games announced at Gamescom was Silent Hills, the latest sequel in Konami’s bestselling horror franchise (which has also spawned two films). The world of gaming and movies combine in this new game, which is being developed by Metal Gear Solid V: The Phantom Pain creator Hideo Kojima and Pacific Rim director Guillermo del Toro. The game will star The Walking Dead’s Norman Reedus.
ACE2 as a potential therapeutic target for pandemic COVID-19
After enjoying a weekend of football in Manchester, David Beckham quickly jetted across the Pond to New York last night to spend Valentine’s Day with his p
Diagnostic technologies for COVID-19: a review
她曾为Glitzy Girl、Sally Miller和Purple Pixies等服装公司担任模特，也为《Teen Vogue》《Cosmopolitan》《Elle》和《Seventeen》等杂志拍摄照片。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Are there any differencesbetween writing a light novel and writing an anime?
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Facebook CEO Mark Zuckerberg
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
这款高端机型将成为苹果产品阵容的一名新成员，加入去年发布的、升级步伐较小的iPhone 7和iPhone 7 Plus的行列。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Walt Disney Pictures and Lucasfilm have promised a Star Wars film every winter after the release of Star Wars: The Force Awakens. These movies will be spin-offs to the main films.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
People were busy launching businesses or making innovations.
5. Bank of America Corp.
Influenza neuraminidase: A druggable target for natural products
Miranda Lambert “Bathroom Sink” (RCA Nashville)
Admittedly, choosing the most clichéd gender colors can seem a bit simplistic, but Pantone has a broad constituency to manage; this is not about the cutting edge, but the big middle.
It is a struggle for power contained by understandings and institutions.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
今年，我最喜欢的人物报道可能是Kiki Zhao对中国目前读者最多的诗人之一余秀华激动人心的描写。余秀华是一个了不起的人。她患有脑瘫，过去41年里大部分时间生活在农村，在一张矮桌子上写作。高中没毕业的她说自己“在能读它们（名著）之前，我就知道如何写作了”。现在，她受邀前往斯坦福大学等地，她不愿被比作艾米丽·迪金森(Emily Dickinson)。
The role of biosensors in the detection of emerging infectious diseases
I formerly had an Android device (even though I have had a MacBook since 2009 – weird, I know). After switching this summer, I quickly realized the power of iPhone “Reminders.” Each time a reminder is due, your iPhone buzzes and displays a pop-up. You can snooze it or mark as completed. In addition, you can set up recurring reminders, which are perfect for remembering to mail estimated quarterly tax payments, renewing subscriptions, running payroll and other things you tend to forget.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
2010 U.S. unemployment rate (average): 10.2%
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
8. How to dip dye hair
Also important to EMBA entrepreneurs was the support of their school and alumni network. About three-quarters of entrepreneurs thought that both the school and their alumni network were helpful or very helpful when setting up their company. “Alumni support was key to getting the idea vetted and getting the right contacts needed for the business”, said one.
7. Pemuteran, Indonesia-Bali's pemeturan has sites for scuba diving among coral-covered Buddha statues, while ground-level offerings include beachfront resorts and restaurants.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
But pop's wider world also offered a lot of pleasures from artists all over the spectrum, such as the 20th century legends like Blondie and Tori Amos, and upstarts like Dua Lipa and Girl Ray.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
要让Airbnb退市，可能没那么容易。最近，昆尼皮亚克大学(Quinnipiac)开展的一项民意调查表明，56％的受访者认为，应该允许纽约人将房间租给陌生人。“我们不想把房子变成旅馆，但是与此同时，人们有时会想把自己的公寓租出去。”霍尔斯特德管理公司(Halstead Management Company)的总裁保罗·R·戈特塞根(Paul R. Gottsegen)说。该公司打理着纽约市250处住宅物业。
Inhibition of SARS coronavirus helicase by bismuth complexes
The disclosure form also warns forex buyers that they are not allowed to exploit others’ exchange quotas. Previously, aggregating quotas from multiple individuals was a common technique that grey-market money changers used to obtain large sums of foreign exchange.
The Veterans Day holiday, which pays tribute to all men and women who have served in the U.S. military, dates back to 1919, when President Woodrow Wilson proclaimed November 11 as Armistice Day to celebrate the end of fighting exactly one year earlier in World War One - "the war to end all wars" - between Germany and the allied nations of Britain, France and the United States. The armistice famously went into effect at "the eleventh hour of the eleventh day of the eleventh month."
Plastic surgery has long been big business in the US, but now the trend is sweeping across Asia.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Unfortunately for May, the big drop in the pound since the Brexit vote means her salary has plunged in dollar terms.
Despite relatively low comparative competition earnings and salary, the pair were the two highest earners in regards to endorsement deals last year, with 17-time Grand Slam champion Federer earning pound 41 million.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
What’s more, a Fiat engine not only places among Wards’ top 10 for the first time, it’s for an electric motor, the 83-kW unit found under the hood of the diminutive 500e. Unfortunately the car is only sold in California, though market forces might convince the automaker to send it into wider distribution should gas prices gain spike up to the $4.00/gallon mark or above.
Do not forget why you're attending these conferences, who you're doing this for -- we are your own children. You are deciding what kind of world we will grow up in. Parents should be able to comfort their children by saying "everyting's going to be alright" , "we're doing the best we can" and "it's not the end of the world". 不要忘记你们为何而来到这里开会，你们为谁做事情？我们是你们的下一代，你们正在决定我们将要在一个什么样的环境中成长，父母需要能够宽慰孩子们，告诉他们“一切都没问题，那不是世界末日，我们正在尽其所能的改变”。
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Between 1991 and 2010, the cancer mortality rate fell by a whopping 20%, which is more than 10% a decade. One day we will say goodbye to cancer for good.
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A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Jennifer Lawrence is one of the hottest young actresses in Hollywood right now, so it's no surprise that a lot of men find her to be irresistible.
London Business School has topped the European table for the third year running — but continental rivals lead the European schools in the individual rankings used to compile it.
Hannah Kuchler is San Francisco correspondent
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Foreign investment in emerging markets has dropped to the lowest level since the financial crisis as investors are braced for the fallout of the first US interest rate rise in nearly a decade.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
3. Enlisted military personnel
China's National Bureau of Statistics said its property prices index for November showed that new home prices fell 3.7 per cent from a year ago, the third straight annual decline following readings of -2.6 per cent in October and -1.3 per cent in September.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
BEST THROWING TOYS OUT OF PRAM
It is just a common sense that no one wants to see chaos at his doorstep.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Russian President Vladimir Putin says he wants to develop better ties with the United States no matter who wins next year's U.S. presidential election.
The results are based on a survey of 15,870 people across the country in August and September.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
James Bond Themes 4. "Thunderball" by Tom Jones
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
At the forum, tech entrepreneurs also shared their views on virtual reality, which they said will be the most important computing platform over the next five to 10 years.
The Lost Tomb
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
So here are the main items to take into consideration if you’re trying to develop a business platform. These elements constitute will support a smart strategy for any new enterprise:
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
"In the aftermath of recessions, there's always a period of jobless recovery," says John Challenger, CEO of global outplacement firm Challenger Gray & Christmas. "We're certainly not optimistic about seeing much improvement in the unemployment rate in 2010."
A modular microarray imaging system for highly specific COVID-19 antibody testing
Of the large land areas where many people live, only the eastern portion of the United States recorded below-average temperatures in 2014, in sharp contrast to the unusual heat in the West. Some experts think the weather pattern that produced those American extremes is an indirect consequence of the release of greenhouse gases, though that is not proven.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
They should be. We agree on that.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A Sicilian Photographer of the Mafia and Her ‘Archive of Blood’
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
6. How to play guitar
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
'The market for colored diamonds is really, really high, because they are so rare,' he said.
Song “Wind Blowing In The Wheat Field” (Li Jian and Sun Li)
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
In the heart of Wan Chai, on one of Hong Kong’s busiest streets, stands a 33-storey office tower that earlier this year became the second most expensive property to change hands in a city that boasts the world’s costliest property market.
A facile assay for rapid detection of COVID-19 antibodies
Last year was the hottest on earth since record-keeping began in 1880, scientists reported on Friday, underscoring warnings about the risks of runaway greenhouse gas emissions and undermining claims by climate change contrarians that global warming had somehow stopped.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
May everything beautiful and best be condensed into this card. I sincerely wish you happiness, cheerfulness and success.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
贝尼托.墨索里尼(Benito Mussolini)和阿道夫.希特勒(Adolf Hitler)就是煽动家变身独裁者的经典例子。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
It was the age of wisdom, it was the age of foolishness…
Anti-HIV drug repurposing against SARS-CoV-2
Topped with golden leaves and flavored with champagne, the confection was sold for $100 a pop.
Never accept the job immediately. Say you need to think about it overnight. Once you sign on the dotted line there's no room for negotiation.
She had recently emerged as the right hand of her father, the former Prime Minister Nawaz Sharif. But corruption charges are clouding her rapid rise.
Length-scale dependence of protein hydration-shell density
Brian Kendrella, president of New York-based Stack's Bowers Galleries, says the auction drew half a dozen bidders from six countries. The winning bidder Thursday was an individual collector from Asia who asked to remain anonymous.
Alice Schwarzer, who has battled for women’s rights for years, is stunned that “an old-school sexist” like Donald J. Trump could win the United States presidency.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
"That of course is in keeping with all of the developments that we have seen in China in recent years, including the current enormous emphasis on innovation as a major component in the transition of the Chinese economy from 'Made in China' to 'Created in China'," he said.
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Song “Embrace Happiness”(Kelly Chen)